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KINGS
carries one of the largest inventories of Fertility medications in
the New York area. |
Follistim™
Humegon
Fertinex™
Repronex 75
Progesterone Capsules & Suppositories
Crinone®
Lupron
Pregnyl
Profasi
Serophene/Clomid
Diagnostic Tests
Email: info@kingsrx.com

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INFERTILITY INFO
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1-800-RxKings |
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1-800-(795-4647) |
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Ten percent
to 15 percent of couples are infertile, defined as the inability to become
pregnant after 1 year of frequent, unprotected sexual intercourse.
Infertility is not the same thing as sterility – the inability to
conceive a child under any circumstance. Often, a diagnosis of infertility
simply means that becoming pregnant is a challenge – but this
challenge can be dramatically aided by medical treatment. |
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Causes
| Every month, a substance called
follicle-stimulating hormone (FSH) is secreted by a woman’s pituitary gland,
signaling the ovaries to mature an egg follicle (a fluid filled capsule). When
one or sometimes two of these follicles have reached a mature size, the
pituitary gland releases another substance called lutenizing hormone (LH). LH
carries the message for the "lead follicle" – or biggest follicle
– to release its egg. The egg then travels to the fallopian tube. For
pregnancy to occur, sperm must unite with the egg in the fallopian tube.
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However, for a significant number of couples attempting to get pregnant,
something goes wrong in the process of ovulation and fertilization. Infertility
can result from a reproductive abnormality in the man, the woman, or both. Fifty
percent to 70 percent of the time, the woman is the infertile partner. Ovulation
disorders, including irregular or absent menstrual periods due to hormonal
deficiencies or imbalances, are frequently the cause of female infertility.
Causes of male infertility include low sperm count, poor sperm motility
(movement), inability of sperm to penetrate the egg, vasectomy reversals and
duct (vas deferens) obstructions.
Fertility drugs are the primary
treatment for women who are infertile due to ovulation disorders. These
medications use different mechanisms to regulate or induce ovulation. In
general, they exert actions designed to work like natural FSH and LH.
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Current fertility medications include:
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Clomiphene citrate – Usually used to
regulate ovulation in women who have irregular menstrual periods. It causes
the pituitary gland to release more FSH and LH, which stimulates the growth of
an egg follicle.
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Human menopausal gonadotropin (hMG) –
Most often prescribed for women who do not ovulate on their own. Unlike
clomiphene, which stimulates the pituitary gland, hMG and other gonadotropins
directly stimulate the ovaries
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Human chorionic gonadotropin (hCG) –
Used in combination with clomiphene, hMG and FSH, it stimulates the "lead
follicle," or the biggest follicle, to release its egg.
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FSH – Commonly prescribed for women who
have elevated levels of natural LH, an imbalance often due to polycystic
ovarian syndrome. FSH is essentially hMG without the LH. Like hMG, it works by
stimulating the ovaries to mature egg follicles.
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GnRH – Used in women whose hypothalmus
does not properly release the natural hormone GnRH, which stimulates the
pituitary gland’s release of FSH and LH. GnRH is administered in a pattern
that mimics the natural rhythm.
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GnRH analogs – Used to treat women with
irregular ovulatory cycles who ovulate prematurely (before the lead follicle
is mature enough) during hMG treatment. GnRH analogs deliver constant GnRH to
the pituitary gland, which alters hormone production so a physician can induce
follicle growth with hMG.
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Bromocriptine – Used to treat women
whose ovulation cycles are irregular due to elevated levels of prolactin, the
hormone that stimulates milk production in new mothers. It inhibits prolactin
production. |
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Fertility drugs are occasionally responsible for multiple births. While
clomiphene citrate only rarely results in pregnancy with more than twins, hMG
and FSH carry a greater risk of causing multiple births. About 15 percent to 25
percent of hMG and FSH treatment cycles result in multiple pregnancies – about
two-thirds being twins and one-third being triplets or more. As a rule, the
greater the number of fetuses, the higher the risk of premature labor. Babies
born prematurely are at increased risk for a number of medical and developmental
problems. Some steps are available to reduce the risk of multiple pregnancies. If a
woman requires an hCG injection to trigger ovulation, and ultrasound exams show
that too many follicles have developed, she and her physician can decide to
withhold the hCG injection. However, for many couples, the desire to become
pregnant overrides concerns about conceiving multiple babies.
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If too many babies are conceived, the removal of one or more fetuses (multifetal
pregnancy reduction) can offer improved survival odds for the strongest fetuses.
However, this presents serious emotional and ethical challenges for many people.
Couples considering fertility drug treatment should discuss this possibility
with their doctors before starting therapy.
Some studies have suggested a link between fertility drugs and an increased,
long-term risk of developing ovarian cancer. However, in 1998, a large study
showed no association between fertility drugs and ovarian cancer. Research is
ongoing on this issue. This also may be an important topic to discuss with your
doctor before initiating treatment with fertility drugs.
Assisted reproductive technologies (ARTs) offer another option for treating
infertility in both women and men.
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The most widely known ART for female infertility is in vitro fertilization in
which an egg is retrieved from the woman’s ovary, fertilized in the
laboratory, and implanted as an embryo in her uterus. In the United States, in
vitro techniques consistently have led to pregnancy rates in the range of 25
percent for each time eggs are retrieved from a woman.
Unlike other male infertility treatments that emphasize increasing the
quantity or quality of sperm, ICSI works with individual sperm. With ICSI, a
single sperm is drawn into a microscopic needle. This individual sperm is then
injected directly into the egg, dramatically improving the likelihood of
fertilization.
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Other ARTs and related techniques currently in use include:
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Gamete (egg and sperm) intrafallopian transfer (GIFT)
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Sperm and embryo freezing and storage
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Electroejaculation/microsurgical epididymal sperm aspiration |
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